Male with Absent Vas Deferens + Female Aged 38: How Did They Find Their Hope?

For many families, IVF is not just a medical procedure—it is a journey filled with hope and perseverance.

Today, we share a real case from a couple served by Huanqiu Xinsheng. The husband had congenital absence of the vas deferens, making natural conception almost impossible. The wife, aged 38, had adequate ovarian reserve but faced fertility challenges associated with advanced maternal age. Through scientific assessment, a personalized treatment plan, and the collaborative efforts of a professional team, they ultimately obtained 14 blastocysts, providing more opportunities for subsequent pregnancy.

Basic Information

Male Partner

The male partner was diagnosed with congenital absence of the vas deferens, a congenital anatomical abnormality. Due to the missing vas deferens, sperm cannot be released through the normal pathway, making natural conception virtually impossible.

After evaluation by the specialist team at Danruo Reproductive Medical Center in Thailand, a testicular sperm aspiration (TESA) approach was chosen to directly obtain sperm from the testes, preparing for subsequent ICSI (intracytoplasmic sperm injection).

Given the limited number of sperm retrieved, the laboratory employed two sperm preservation techniques:

• Rare sperm cryopreservation: a total of 7 straws were preserved;
• Single sperm cryopreservation: a total of 40 individual sperm were stored, meeting the needs for subsequent ICSI.

For patients with this condition, mature laboratory techniques and meticulous handling are a critical part of the entire treatment process.

Female Partner

The female partner is 38 years old, in the advanced maternal age category.

Systematic examination showed that her baseline levels of AMH, FSH, LH, and other indicators were generally favorable, with adequate ovarian reserve. Ultrasound examination revealed a moderate antral follicle count (AFC), suggesting good potential for ovarian stimulation.

However, the physician noted that with increasing age, egg quality decline and the risk of chromosomal abnormalities gradually rise, necessitating a more precise stimulation protocol.

Based on her condition, Danruo Reproductive Medical Center in Thailand ultimately designed a personalized PPOS (progestin-primed ovarian stimulation) protocol to maintain egg quality while minimizing the risk of ovarian hyperstimulation syndrome (OHSS).

Stimulation and Egg Retrieval Results Exceeded Expectations

After the full stimulation cycle, satisfactory results were achieved:

• 21 oocytes were successfully retrieved;
• 15 of these were mature MII oocytes;
• 6 were immature oocytes.

Subsequently, all 15 mature oocytes underwent ICSI.

The final results were:

• 13 oocytes showed normal fertilization (2PN);
• 2 oocytes showed 1PN fertilization.

Meanwhile, the remaining 6 immature oocytes underwent IVM (in vitro maturation) culture. Of these, 5 matured successfully and all fertilized normally (2PN). After extended culture, 3 formed Day 5 blastocysts.

In total, the full cycle produced 14 high-quality blastocysts, providing ample options for subsequent embryo screening and transfer.

Why Were These Results Achieved?

Many people might assume that obtaining 14 blastocysts was simply good luck. In reality, every outcome is the result of coordinated efforts across multiple steps.

First, a precise sperm retrieval plan was tailored for the male partner's congenital absence of the vas deferens. Viable sperm were successfully obtained via TESA, and advanced cryopreservation techniques ensured a stable supply for the entire treatment.

Second, for the 38-year-old female partner, the physician did not use a one-size-fits-all protocol. Instead, a personalized stimulation plan was designed based on ovarian function, baseline hormone levels, and antral follicle count, leading to better oocyte maturation rates.

In addition, a well-established and stable embryology laboratory was critical to the entire process. From ICSI fertilization and IVM culture to blastocyst culture, every step required an experienced laboratory team.

It is the accumulation of these details that ultimately helped the couple achieve favorable blastocyst culture results.

Why Are More Families Choosing Thailand for IVF?

In recent years, an increasing number of families have chosen to undergo IVF treatment in Thailand. In particular, third-generation IVF in Thailand has attracted attention due to its mature laboratory systems, standardized medical procedures, and extensive clinical experience.

For families facing male factor infertility, advanced maternal age, recurrent implantation failure, chromosomal abnormalities, or genetic disease risks, a more scientific and personalized treatment plan can help physicians better manage the entire process.

Of course, every family's situation is different. A plan that works for others may not be suitable for everyone. Whether third-generation IVF in Thailand is appropriate depends on a professional evaluation.

Huanqiu Xinsheng: Accompanying Every Family on Their Overseas Journey

For many families traveling to Thailand for the first time, the real concerns go beyond the medical treatment itself—they also include language barriers, hospital selection, accommodation, treatment procedures, and cross-border travel arrangements. As a professional organization specializing in overseas fertility treatment, cross-border childbirth, and medical accompaniment, Huanqiu Xinsheng is committed to providing science-based, reassuring one-stop services tailored to each family's actual situation.

From initial consultation, hospital matching, doctor appointments, and travel planning to medical translation, full-time accompaniment during treatment, and continued follow-up after returning home, Huanqiu Xinsheng aims to help families navigate their entire fertility journey with greater confidence and ease.